Publications
(selected publications)
Korzekwa KR, Jones JP, and Gillette JR. (1990) Theoretical studies on cytochrome P-450 mediated hydroxylation: A predictive model for hydrogen atom abstractions. J. Amer. Chem. Soc. 112: 7042-7046.
Jones JP, and Urbauer JL. (1991) Theoretical kinetic isotope effects for hydride transfer from formate to carbon dioxide: A comparison of theory with experiment. J. Comp. Chem. 12: 1134-1141.
Jones JP, Trager WF, and Carlson TJ. (1993) The binding and regioselectivity of reaction of (R) and (S)-nicotine with cytochrome P-450cam: Parallel experimental and theoretical studies. J. Amer. Chem. Soc. 115: 381-387.
Korzekwa KR, Jones JP. (1993) Predicting the cytochrome P450 mediated metabolism of xenobiotics. Pharmacogenetics 3: 1-18.
Dinnocenzo JP, Karki SB, and Jones JP (1993) Isotope effects for the cytochrome P-450 oxidation of substituted N,N-dimethyl anilines. J. Amer. Chem. Soc. 115: 7111-7116.
Yin H, Bennett G, and Jones JP. (1994) Mechanistic studies of UDP-glucuronosyltransferase. Chemico-Biol. Interact. 90: 47-58.
Jones JP, Shou M, and Korzekwa KR (1995). Stereospecific activation of the procarcinogen benzo[a]pyrene to probe the active site of the cytochrome P450 superfamily. Biochemistry, 34: 6956-6961.
Dinnocenzo JP, Karki SB, Jones JP, and Korzekwa KR. (1995) The mechanism of oxidative amine dealkylation by cytochrome P450: Application of isotope effect profiles. J. Am. Chem. Soc., 117: 3657-3664.
Yin H, Anders MW, and Jones JP. (1996) Metabolism of 1,2-dichloro-1-fluoroethane and 1-fluoro-1,2,2-trichloroethane: Electronic factors govern the regioselectivity of cytochrome P450-dependent oxidation. Chem. Res. Toxicol. 9: 50-57.
Jones JP, He M, Trager WF, and Rettie AW (1996) 3D-QSAR for inhibitors of cytochrome P450 2C9. Drug Metabolism and Disposition24: 1-6.
Jones JP, and Korzekwa KR. (1997) Predicting binding affinities and rates of reaction for the P450 superfamily. In: “Methods in Enzymology.” Ed. E. F. Johnson, and M. R. Waterman. Invited Chapter, Vol. 272b, pp. 326-335.
Manchester JI, Dinnocenzo JP, Higgins L and Jones JP. (1997) A new mechanistic probe for cytochrome P450. J. Am. Chem. Soc. 119: 5069-5070.
Iyer KR, Jones JP, Darbyshire JF, and Trager WF. (1997) Intramolecular isotope effects of benzylic hydroxylation of isomeric xylenes and 4,4’-dimethylbiphenyl by cytochrome P450: Relationship between distance of methyl groups and masking of the intrinsic isotope effect. Biochemistry 36: 7136-7143.
Higgins, L, Bennett, G. A., Shimoji, M. & Jones, J.P (1998) Evaluation of Cytochrome P450 Mechanism and Kinetics Using Kinetic Deuterium Isotope Effects. Biochemistry 37: 7036-7046.
Shimoji, M., Yin, H., Higgins, L. Jones, J.P. (1998) Design of a Novel P450: A Functional Bacterial/Human Cytochrome P450 Chimera. Biochemistry, 37: 8848-8852.
Goto, Y., Watanabe, Y., Fukuzumi, S., Jones, J. P. Dinnocenzo, J. P. (1998) Mechanisms of N-Demethylations Catalyzed by High-Valent Species of Heme Enzymes: Novel Use of Isotope Effects and Direct Observation of Intermediates. J. Amer. Chem. Soc. 120: 10762-10763.
Audergon, C., Iyer, K.R., Jones, J.P., Darbyshire, J.F, Trager, W.F. (1999) Experimental and theoretical approaches to study the active site topography of CYP101 (P450cam). J. Amer, Chem. Soc. 121, 41-47.
Haining, R.L., Jones, J.P., Henne, K., Fisher, M.B., Trager, W.F., Rettie, A.E. (1999) Phenylalanine 114 is a Critical, Substrate-Dependent Determinant of Specificity in Human Cytochrome P450 2C9. Biochemistry, 38: 3285-3292.
Koenigs, L.L., Jones, J.P., Friedberg, T., Pritchard, M. P., Shou, M., Rushmore, T.H., Trager, W. F. (2000) Mechanism-Based Inactivation of Cytochrome P450 3A4 by L-754,394. Biochemistry; 39:4276-87.
Rao S, Aoyama R, Schrag M, Trager WF, Rettie A, Jones JP. (2000) A refined 3-dimensional QSAR of cytochrome P450 2C9: computational predictions of drug interactions.J Med Chem; 43:2789-96.
Higgins, L., Korzekwa, K.R., Shou, M., Jones, J.P. (2001) A Method for the Assessment of Reaction Energetics for Cytochrome P450 Mediated Reactions. Archives of Biochemistry and Biophysics, 385, 220-230.
Ekins, S., de Groot, M.J., Jones, J.P. (2001) Pharmacophores and three Dimensional Quantitative Structure Activity Relationship Methods for Modeling Cytochrome P450 Active Sites. Drug Metabolism and Disposition, 29: 936-944.
Rock D, Rock D, Jones JP. (2001) Inexpensive purification of P450 reductase and other proteins using 2 ',5 '-adenosine diphosphate agarose affinity columns. Prot. Express. Pur. , 22: 82-83
French, K. J., Strickler, M. D., Rock, D. A., Rock, D. A., Bennett, G. A., Wahlstrom, J. L. Goldstein, B. M., Jones, J. P. (2001) Benign Synthesis of 2-ethylhexanoic acid by Cytochrome P450cam: Enzymatic, Crystallographic, and Theoretical Studies. Biochemistry, 40: 9532-9538.
Kevin J. French, Dan A. Rock, Denise A. Rock, John I. Manchester, Barry M. Goldstein, and Jeffrey P. Jones* (2002) “Rational Design of Cytochrome P450cam: Understanding the structural basis for the oxidase shunt and improving the benign synthesis of 2-Ethylhexanoic Acid” Arch. Biochem. Biophysics, 398, 188-97.
Jeffrey P. Jones*, Michael Mysinger, Kenneth Ray Korzekwa (2002) “Computational Models for Cytochrome P450: Predictive Electronic Model for Aromatic Oxidation and Hydrogen Atom abstraction” Drug Metabolism and Disposition, 1, 7-12.
Dan A. Rock, Anthony E. Boitano, Jan L. Wahlstrom, Denise A. Rock, and Jeffrey P. Jones* (2002) “The Use of Kinetic Isotope Effects to Delineate the Role of Phenylalanine 87 in P450BM-3 “ Bioorganic Chemistry, 30, 107-118.
Volz, T., Rock, D.A., Jones, J.P. (2002) “Direct Evidence for Two Different Active Oxygen Species in Cytochrome P450BM3 Mediated Sulfoxidation and N-Dealkylkation Reactions.” Journal of the American Chemical Society, 124(33); 9724-9725.
Strickler M, Goldstein BM, Maxfield K, Shireman L, Kim G, Matteson DS, Jones JP.(2003) “ Crystallographic studies on the complex behavior of nicotine binding to P450cam (CYP101).” Biochemistry. Oct 21;42(41):11943-50
Rock DA, Perkins BNS, Wahlstrom J, Jones JP.(2003) “A method for determining two substrates binding in the same active site of cytochrome P450(BM3): an explanation of high energy omega product formation.” Arch. Biochem. Biophysics. 416 (1): 9-16 AUG 1 2003.
Tornero-Velez R, Ross MK, Granville C, Laskey J, Jones JP, DeMarini DM,Evans MV “Metabolism and mutagenicity of source water contaminants 1,3-dichloropropane and 2,2-dichloropropane”Drug Metabolism and Disposition, 32 (1): 123-131 JAN 1 2004.
Dowers TS, Rock DA, Rock DA, Perkins BNS, Jones JP (2004) “An analysis of the regioselectivity of aromatic hydroxylation and N-oxygenation by cytochrome P450 enzymes.”Drug Metabolism and Disposition, 32 (3): 328-332.
Dickmann, L. J., Locuson, C. W., Jones, J. P. and Rettie. A.E. (2004) “Differential Roles of Arg97, Asp293, and Arg108 in Enzyme Stability and Substrate Specificity of CYP2C9.” Mol Pharmacol 65: 842-850.
Locuson,C.W. II, Rock, D.A., and Jones, J.P. (2004), “Quantitative Binding Models for CYP2C9 Based on Benzbromarone Analogues." Biochemistry, Web Release Date: 13-May-2004.
Dowers, T. S., D. A. Rock, D. A. Rock and J. P. Jones (2004). "Kinetic isotope effects implicate the iron-oxene as the sole oxidant in P450-catalyzed N-dealkylation." Journal of the American Chemical Society 126(29): 8868-8869.
Rettie, A., Jones, J.P. (2005) “Clinical and toxicological relevance of CYP2C9: Drug- drug interactions and pharmacogenetics” Annual Review of Pharmacology and Toxicology 45 477-494.
Locuson, C.W., Wienkers, L.C., Jones, J.P., Tracy, T.(2007) "CYP2C9 Protein Interactions with Cytochrome b5: Effects on the Coupling of Catalysis"Drug Metabolism and Disposition, 35(7): 1174-81
Cho, K. B.;Moreau, Y.;Kumar, D.;Rock, D. A.;Jones, J. P.;Shaik, S.
(2007). "Formation of the Active Species of Cytochrome P450 by Using Iodosylbenzene: A Case for Spin-Selective Reactivity." Chemistry: A European Journal 13: 4103-4115.
Torres, R. A.; Korzekwa, K. R.; McMasters, D. R.; Fandozzi, C. M.; Jones, J. P. (2007) "Use of Density Functional Calculations To Predict the Regioselectivity of Drugs and Molecules Metabolized by Aldehyde Oxidase" . J. Med. Chem.; (Article); ASAP Article; DOI: 10.1021/jm0703690
Hudelson, M. G.; Ketkar, N. S.; Holder, L. B.; Carlson, T. J.; Peng, C.; Waldher, B. J.; Jones, J. P. (2008). High Confidence Predictions of Drug−Drug Interactions: Predicting Affinities for Cytochrome P450 2C9 with Multiple Computational Methods, J. Med. Chem.; 2008 Feb 14;51(3):648-54. Epub 2008 Jan 19 DOI: 10.1021/jm701130z
Chi-Chi Peng, Tom Rushmore, Gregory J. Crouch, and Jeffrey P. Jones ” Modeling and Synthesis of Novel Tight-Binding Inhibitors of Cytochrome P450 2C9". Bioorganic and Medicinal Chemistry, 2008 Aor 1; 16(7): 4064-74 Epub 2008 Jan 18. PMID: 18255300
.
Life is good at WSU.
Secondary content can be almost anything. If you are not using this region delete all the content that is in between the div tags with the id ="additional".
A unique richness of students, faculty, location, activities, and organizations creates a full, lively student life at the University. This section gives you the insider's view on student life and a sampling of the opportunities here.
"Glimpses." Students talk about life at WSU
These brief posts are written by WSU students to give you a personal look through their window on campus life.